Computational Methods for Analysis of MALDI-TOF Spectra to Discover Peptide Serum Biomarkers Running head: Computational Methods for Analysis of MALDI-TOF Spectra Authors:
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MALDI-TOF MS combined with magnetic beads for detecting serum protein biomarkers and establishment of boosting decision tree model for diagnosis of systemic lupus erythematosus.
OBJECTIVES To discover novel potential biomarkers and establish a diagnostic pattern for SLE by using proteomic technology. METHODS Serum proteomic spectra were generated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) combined with weak cationic exchange magnetic beads. A training set of spectra, derived from analysing sera from 32 patients with...
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تاریخ انتشار 2009